Long-term depression, or LTD, is a process by which synaptic connections between neurons are weakened. Although the functions of LTD are not completely understood, it may be important to memory formation---perhaps by resetting previous synaptic changes to allow for new memories to be formed via long-term potentiation (LTP). In this video, I discuss the best understood mechanism underlying LTD, which involves AMPA and NMDA glutamate receptors.
Welcome to Neuroscientifically Challenged! All of the content for the site is collected on this home page, but if you're looking for specific types of content you can use the menu bar above. By clicking on Articles, you'll find links to blog articles on a variety of different neuroscience topics. The Know Your Brain link will take you to a listing of reference articles, each of which deals with a different part of the nervous system. Clicking on the 2-Minute Neuroscience Videos link will take you to an assortment of 2-minute videos that each teach you about a different aspect of neuroscience. And the Glossary contains a large selection of definitions for common neuroscience terms.